VDR is a Virtual Data Room that provides secure access www.dataroomstips.info/best-sales-enablement-software/ to secure documents related to business transactions. VDRs are employed to perform due diligence during mergers and acquisitions and help companies organize and share important documents with investors and other stakeholders. VDRs are also used to store and organize invoices, contracts, and other documents for legal reasons, such as litigation or estate planning.
Members should review their current procedures and equipment for their vessels with VDR/S-VDRs installed. It is also recommended to upgrade and replace any that are outdated or do not meet minimum safety standards.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes control the production of proteins that are involved in a myriad of physiological processes.
The VDR is present in neurons as well as a subset of glial cells, which form part of the brain. In the primary hippocampal culture of rat it was observed that immunoreactivity for VDR was observed in the oligodendrocytes. The VDR is also found in human neuroblastoma as well as astrocytes. Treatment of HL-60 myeloblastleukemia cells with 1,25(OH)2D3 caused monocyte-like differentiation and an increase in the levels of VDR protein. This effect was inhibited by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.